Diane dietz january 25, 2018 page 2 your company sells a number of products containing benzophenone, and is required under californias safe drinking water and toxic enforcement act of 1986, commonly known. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient benzophenone3. Hydroxy4methoxybenzophenone, also known as benzophenone 3 bp 3, is a commonly used ultraviolet filter in skincare and as a food additive. Benzophenone3, listed as oxybenzone, and benzophenone4 and 5, listed as sulisobenzone and sulisobenzone sodium, respectively, are included in annex vii, part 1 uv filter which cosmetic products may contain of the cosmetics directive of the european union. Bp3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. The suspected endocrine disruptor bp 3 has been detected in the air and settled dust of homes and is expected to redistribute from its original sources to other indoor compartments, including clothing. Benzophenone is a different chemical than benzophenone 3 also called oxybenzone and benzophenone 4 also called sulisobenzone. The current submission contains the following documents. Concentrations of the sunscreen agent benzophenone3 in.
Benzophenone3 oxybenzone is used in many sunscreens and some other personal care products to protect skin from sun damage. This study aimed to 1 provide descriptive information about prostate specific antigen levels and 2 examine the association. Oxybenzone or benzophenone3 or bp3 trade names milestab 9, eusolex 4360, escalol 567, kahscreen bz3 is an organic compound. It is a paleyellow solid that is readily soluble in most organic solvents. According to the study, the average total amount of benzophenone3 excreted was 3. Colipa letter stating that the use level of bp3 as a uvfilter does not exceed 6% for. Benzophenone 3 bp 3 is a naturally occurring chemical found in some flowering plants.
Determination of trace levels of benzophenonetype ultraviolet filters in real matrices by bar adsorptive microextraction using selective sorbent phases. Bp 3 absorbs and scatters the suns harmful ultraviolet uv rays. Benzophenone 3, listed as oxybenzone, and benzophenone 4 and 5, listed as sulisobenzone and sulisobenzone sodium, respectively, are included in annex vii, part 1 uv filter which cosmetic products may contain of the cosmetics directive of the european union. Benzophenone3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. Applications galsorb benzophenone3 being a broadband uv filter, it can be used in day cream to prevent aging of skin and to protect the lips. Galsorb benzophenone 3 is an oil soluble sunscreen agent. Given its physical and chemical properties, we hypothesized that. Benzophenone3 oxybenzone, benzophenone4 sulisobenzone. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Widespread exposure of humans to benzophenone3 bp3 is a concern due to this compounds potential to disrupt endocrine function. Benzophenone3 oxybenzone and benzophenone4 sulisobenzone are chemical uv absorbers solid powder at normal temperature. Moreover it seems that oxybenzone can build up in the body.
Benzophenone3 also known as bp3 or oxybenzone is added to sunscreens, plastics, and some coatings to filter uv radiation. Introduction background we use the term cosmetics in this report to denote a wide variety of personal care products used by people of all genders and ages. Benzophenone3 2hydroxy4methoxybenzophenone, oxybenzophenone bp3, a commonly used sunscreen agent that absorbs and dissipates ultraviolet radiation, is used in a variety of cosmetic products gonzalez et al. It is a naturally occurring chemical found in various flowering plants as well as being an organic component of many. Toxicopathological effects of the sunscreen uv filter, oxybenzone. Benzophenone3 bp3 is a naturally occurring chemical found in some flowering plants.
Benzophenone3 bp3 benzophenone3 bp3 is a naturally occurring chemical found in some flowering plants. Benzophenone3 bp3 factsheet national biomonitoring. Biphenyl occurs as colorless leaflets that are insoluble in water. Exposure may occur by using consumer products that contain benzophenone. Bp3 absorbs and scatters the suns harmful ultraviolet uv rays. The inci name for this ingredient is benzophenone3. Oct 10, 2008 according to the study, the average total amount of benzophenone 3 excreted was 3. Benzophenone4 is readily soluble in water, propylene glycol, glyerin, ethanol and isopropyl alcohol. Benzophenone is the organic compound with the formula c 6 h 5 2 co, generally abbreviated ph 2 co. Jan 28, 2020 sunscreen octocrylene, ethylhexyl methoxycinnamate, benzophenone3, butyl methoxydibenzoylmethane stick out of scope out of scope for rxnorm and will not receive rxnorm normal forms. It is a naturally occurring chemical found in various flowering.
Oxybenzone belongs to the class of aromatic ketones known as benzophenones. Inadequate when used alone, benzophenone 3 absorbs uvb and short uva rays but is a relatively weak chemical uv absorber. Oxybenzone, also known as benzophenone3, is an organic. Hazardous in case of skin contact irritant, sensitizer, of eye contact irritant, of ingestion, of inhalation. Recall that oxidation is a loss of electrons while reduction is a gain of electrons oil rig. Benzophenone3 is proposed to be continued for use in sunscreen products at a maximum concentration at 10% weightweight. Exposure to benzophenone3 and reproductive toxicity. It was clear to see that after 3 to 5 days after the last application there was. Parameter result benzophenone3 octocrylene octinoxate octisalate retention time min 6. Bp3 also has been used as ultraviolet stabilizer in plastic surface coatings for food packaging to prevent polymer or. Large concentrations of similar phenolic compounds have been detected in urine, amniotic fluid, and placental tissue, thereby raising questions about its impact on reproduction.
Date hs code description origin country port of discharge unit quantity value inr per unit inr nov 09 2016. Background submission i on the uvfilter oxybenzone the inn name, also known as benzophenone3 or 2hydroxy4methoxybenzone, has been submitted by colipa1. Benzophenone is a different chemical than benzophenone3 also called oxybenzone and benzophenone4 also called sulisobenzone. Please login to display the rating of all cosmetics. Bp3 can be metabolized by phase i and phase ii reactions of the human cytochrome p450 system. The benzophenone is activated by uv light to an extremely reactive tripletstate ketone, which can insert into ch, nh, and other structures, resulting in a covalent bond chapter 3, section 7. Apoptosis induced by the uv filter benzophenone3 in mouse.
Large concentrations of similar phenolic compounds have been detected in urine, amniotic fluid, and placental tissue, thereby. Pdf hydroxy4methoxybenzophenone, also known as benzophenone3 bp3, is a commonly used ultraviolet filter in skincare and as a food additive find. Doubly bonded ep and be15 molecules and their reactions with h2, acetonitrile, benzophenone, and 2,3dimethylbutadiene. Background submission i on the uvfilter oxybenzone the inn name, also known as benzophenone 3 or 2hydroxy4methoxybenzone, has been submitted by colipa1. Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. It is a broad spectrum sunscreen active with maximal uv absorbance in the 320400 nm range uva. Dermal uptake of benzophenone3 from clothing environmental. Combustion products may include carbon oxides or other toxic vapors. Apr 07, 2017 benzophenone3 bp3 is a naturally occurring chemical found in some flowering plants. The capability of benzophenone3 bp3 to absorb and dissipate. Nevertheless, metabolic transformation pathway and the transformation products of bp3 in.
Often benzophenone is used in combination with other chemical absorbing sunscreens to augment and stabilise the final product. Oxybenzone is an emerging contaminant of concern in marine environmentsproduced by swimmers and. Benzophenone 3 also known as bp 3 or oxybenzone is added to sunscreens, plastics, and some coatings to filter uv radiation. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient benzophenone 3. The benzophenone is activated by uv light to an extremely reactive tripletstate ketone, which can insert into ch, nh, and other structures, resulting. Reliance value innovation shanghai sunwise chemical co. The effects of the main experimental parameters were. Benzophenone 4 is readily soluble in water, propylene glycol, glyerin, ethanol and isopropyl alcohol. Benzophenone 3, or oxybenzone, primarily functions as a photostabilizer and sunscreen. Applications galsorb benzophenone 3 being a broadband uv filter, it can be used in day cream to prevent aging of skin and to protect the lips. Sunscreen octocrylene, ethylhexyl methoxycinnamate, benzophenone3, butyl methoxydibenzoylmethane stick out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Both cover uvb and short uva uva2 range but are relatively weak sunscreens, inadequate when used alone. The companys origins and strength lie in a profound understanding of the supply and the.
It is a white solid that is soluble in organic solvents. Benzophenone 3 is proposed to be continued for use in sunscreen products at a maximum concentration at 10% weightweight. Pdf concentrations of the sunscreen agent benzophenone3. Benzophenone is persistent, bioaccumulative and toxic pbt. Because it is not yet known how long the material is stored, or whether it is important, gonzalez suggested that parents of small children avoid using sunscreens that contain benzophenone 3, to be on the safe side. Among the vast selection of sunscreen active ingredients, benzophenone3 is classified as a chemical sunscreen agent. They are both very stable and protect and augment other uv absorbers. Effects of oxybenzone benzophenone3 on phytoplakton. In this study, the adsorption of a hydrophobic molecule, benzophenone3 bz3 was investigated onto three adsorbents.
Many of these chemicals have been shown to have adverse effects on reproductive organs and hormones, both in vitro and in vivo. The capability of benzophenone 3 bp 3 to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. Derivatives of benzophenone, such as benzophenone2 bp2 and oxybenzone benzophenone3 or bp3 are common ingredients in sunscreen. Galsorb benzophenone3 is an oil soluble sunscreen agent. Concentrations of the sunscreen agent benzophenone3 in residents of the united states. The suspected endocrine disruptor bp3 has been detected in the air and settled dust of homes and is expected to redistribute from its original sources to other indoor compartments, including clothing. For this reason, it is produced for use as sunscreen in lotions, conditioners, and cosmetics. Hazards identification potential acute health effects.
Dermal uptake of benzophenone3 from clothing dtu orbit. Oxybenzone or benzophenone 3 or bp 3 trade names milestab 9, eusolex 4360, escalol 567, kahscreen bz 3 is an organic compound. Oxybenzone may be used at concentrations up to 10%, and products containing 0. Bp 3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. Cosmetics containing ingredients linked to cancer or. In an investigation carried out 25 people applied sun cream, containing 4% oxybenzone, twice a day over 5 consecutive days. These chemicals are not listed under proposition 65. National health and nutrition examination survey 20032004. Berje is a familyowned business that has been in operation for six decades. Because it is not yet known how long the material is stored, or whether it is important, gonzalez suggested that parents of small children avoid using sunscreens. Derivatives of benzophenone, such as benzophenone 2 bp2 and oxybenzone benzophenone 3 or bp3 are common ingredients in sunscreen. Three groups each of four female mice were treated daily with benzophenone3 at concentrations of 12.
Cosmetics containing ingredients linked to cancer or reproductive harm 3 california department of public health california safe cosmetics program august 2016 part 1. Toxicopathological effects of the sunscreen uv filter. Hydroxy4methoxybenzophenone, also known as benzophenone3 bp3, is a commonly used ultraviolet filter in skincare and as a food additive. Archives of environmental contamination and toxicology, 702, 265288. Benzophenone 3 is also added to packaging and some consumer products, such as cosmetics and paints, to protect the products from sun damage. Where the world comes to its senses berje is a global distributor of essential oils and aromatic chemicals.
Benzophenone is used in personal care products such as lip balm and nail polish to protect the products from uv light. Benzophenone3, or oxybenzone, primarily functions as a photostabilizer and sunscreen. Feb 01, 2019 in this study, the adsorption of a hydrophobic molecule, benzophenone 3 bz 3 was investigated onto three adsorbents. Oxybenzone is an emerging contaminant of concern in marine environmentsproduced by swimmers and municipal, residential, and boatship wastewater discharges. Sds of benzophenone, safety data sheets, cas 119619. Safety data sheet according to 29cfr19101200 and ghs rev. The capability of benzophenone3 bp3 to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent.
Among the vast selection of sunscreen active ingredients, benzophenone 3 is classified as a chemical sunscreen agent. It provides uvb absorption as well as some absorption in uva region 320340 nm. Substituted benzophenones such as oxybenzone and dioxybenzone are used in sunscreen. A comparative study for all adsorbents with batch adsorption experiments was achieved to determine the optimal conditions. Fourth national report on human exposure to environmental. Benzophenone 3 oxybenzone and benzophenone 4 sulisobenzone are chemical uv absorbers solid powder at normal temperature. Health sciences research commons gw research days 2016.
Benzophenone 119619 100 toxicological data on ingredients. The effects of the main experimental parameters were determined such. Pdf exposure to benzophenone3 and reproductive toxicity. Urinary measurements of bp3 have been used as a biomarker of exposure. Benzophenone3 2hydroxy4methoxybenzophenone, oxybenzone, 2oh4 meobp or bp3 is a commonly used sunscreen agent, absorbing.
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